MAPK7 CLIA Kit for Human(Homo sapiens) | EIAab.comMAPK7 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > MAPK7(Gene name) > Human

MAPK7 (Gene name),

Mitogen-activated protein kinase 7 (Protein name ), MK07_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MAPK7(BMK1;ERK5;PRKM7);

Protein name:

Mitogen-activated protein kinase 7(MAP kinase 7;MAPK 7);

Alternative:

Extracellular signal-regulated kinase 5(ERK-5);Big MAP kinase 1(BMK-1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with MAP2K5. Forms oligomers (By similarity). Interacts with MEF2A, MEF2C and MEF2D; the interaction phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D.

Function:

Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways.

Subcellular Location:

Cytoplasm Nucleus Translocates to the nucleus upon activation.

Protein Attributes:

Sequence length:

816

Sequence:

50:

100:

150:

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250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

816:

MDSPMLLADL | PDLQDP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q13164

UniGene:

Hs.150136

STRING:

9606.ENSP00000311005

String:

Q13164

KEGG:

hsa:5598

Pfam:

PF00069

MIM:

602521

Uniprot:

Q13164

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ELISA Kit for Human MAP kinase 7

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E9212h

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ELISA Kit for Human MAP kinase 7

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E9212m

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ELISA Kit for Human MAP kinase 7

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E9212r

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ELISA Kit for Human MAP kinase 7

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E9212b

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96T

CLIA Kit for Human MAP kinase 7

Cat.:

U9212m

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96T

CLIA Kit for Human MAP kinase 7

Cat.:

U9212h

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96T

CLIA Kit for Human MAP kinase 7

Cat.:

U9212b

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96T

CLIA Kit for Human MAP kinase 7

Cat.:

U9212r

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Polyclonal Antibody for Human MAP kinase 7

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P9212Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human MAP kinase 7

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P9212Rb-h

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Polyclonal Antibody for Human MAP kinase 7

Cat.:

P9212Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human MAP kinase 7

Protein for Human MAP kinase 7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Primary structure of BMK1: a new mammalian map kinase."
Lee J.-D. , Ulevitch R.J. , Han J.
Biochem. Biophys. Res. Commun.213:715-724(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
tissue: Placenta.
2.

"Components of a new human protein kinase signal transduction pathway."
Zhou G. , Bao Z.Q. , Dixon J.E.
J. Biol. Chem.270:12665-12669(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH MAP2K5;TISSUE SPECIFICITY
tissue: Fetal brain.
3.

"Identification and characterization of mErk5-T, a novel Erk5/Bmk1 splice variant."
McCaw B.J. , Chow S.Y. , Wong E.S.M. , Tan K.L. , Guo H. , Guy G.R.
Gene345:183-190(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
tissue: Placenta.
4.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Spleen.
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Muscle.
tissue: Pancreas.
7.

Bienvenut W.V. , Fleming J. , Leug H.Y.
Submitted (2010-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-35; 75-98; 119-131; 198-205; 296-343; 377-392; 468-485; 489-505; 544-571; 720-735 AND 798-816;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Hepatoma.
8.

"BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C."
Kato Y. , Kravchenko V.V. , Tapping R.I. , Han J. , Ulevitch R.J. , Lee J.-D.
EMBO J.16:7054-7066(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;SUBCELLULAR LOCATION;MUTAGENESIS OF 219-THR--TYR-221
9.

"Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor."
Kato Y. , Tapping R.I. , Huang S. , Watson M.H. , Ulevitch R.J. , Lee J.-D.
Nature395:713-716(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
10.

"BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase."
Hayashi M. , Tapping R.I. , Chao T.H. , Lo J.F. , King C.C. , Yang Y. , Lee J.D.
J. Biol. Chem.276:8631-8634(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SGK1
11.

"Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival."
Dong F. , Gutkind J.S. , Larner A.C.
J. Biol. Chem.276:10811-10816(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-720 AND THR-733;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
13.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction."
Yang Q. , Liao L. , Deng X. , Chen R. , Gray N.S. , Yates J.R. III , Lee J.D.
Oncogene32:3156-3164(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION;INTERACTION WITH PML
15.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-535 AND ALA-550

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